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Clinical

Ebola symptoms and differential diagnosis

Most early Ebola symptoms are indistinguishable from malaria, typhoid, or influenza. The two-phase clinical picture, the warning signs, and what to do if you may have been exposed.

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What are the symptoms of Ebola?

Sudden fever, severe headache, muscle pain, and fatigue, 2 to 21 days after exposure. Most cases progress in 5 to 7 days.

Early Ebola symptoms appear suddenly: high fever (usually above 38.5°C), intense headache, muscle and joint pain, profound fatigue, and sore throat. This "dry phase" typically lasts 3 to 5 days and overlaps heavily with malaria, typhoid, and influenza, which is why laboratory testing is required to confirm Ebola. A "wet phase" follows, with vomiting, diarrhoea, abdominal pain, hiccups, rash, and sometimes unexplained bleeding (gums, eyes, injection sites, stool). The incubation period from exposure to first symptoms ranges 2 to 21 days, with most cases developing symptoms within 8 to 10 days. Ebola is not contagious before symptoms begin.

Sources: WHO Ebola fact sheet, CDC Ebola symptoms.

This page is editorial reference, not medical advice. If you may have been exposed to Ebola, contact your local public health authority before visiting a clinic so triage can prepare isolation procedures.

Phase 1 · Early "dry" phase (days 1–4)

  • · Sudden onset of fever (often above 38.6 °C)
  • · Severe fatigue and malaise
  • · Muscle pain and joint aches
  • · Headache
  • · Sore throat
  • · Loss of appetite

These symptoms are indistinguishable from many common tropical infections. Laboratory testing is required to confirm or rule out Ebola.

Phase 2 · Progressive "wet" phase (days 5+)

  • · Vomiting and abdominal pain
  • · Profuse watery diarrhoea (a major cause of dehydration death)
  • · Rash on the trunk
  • · Impaired liver and kidney function
  • · In a minority of patients: bleeding from the gums, bloody stools, blood in the eyes
  • · Late-stage: confusion, agitation, multi-organ failure

Mortality is driven primarily by fluid and electrolyte loss and by septic complications, not by the classic "haemorrhagic" presentation that the older name (Ebola haemorrhagic fever) implies.

Differential diagnosis

Most patients presenting with fever in a region of active Ebola transmission do not have Ebola. The clinical task is to identify the much smaller subset who do. Common alternatives:

Condition Overlapping symptoms Distinguishing features Diagnostic confirmation
Malaria Fever, headache, fatigue, muscle pain Cyclical fever, splenomegaly; common across DRC and Uganda regardless of Ebola activity Rapid diagnostic test or microscopy
Typhoid fever Fever, abdominal pain, fatigue Step-ladder fever pattern, relative bradycardia, rose spots Blood culture
Lassa fever Fever, sore throat, retro-orbital pain Geographic distribution centred on West Africa; bleeding less prominent PCR / IgM
Marburg virus disease All Ebola-like symptoms Clinically indistinguishable from Ebola; require lab differentiation PCR with filovirus panel
Dengue fever Fever, headache, muscle pain Retro-orbital pain, biphasic fever, leukopenia NS1 antigen or PCR
Yellow fever Fever, jaundice, vomiting Jaundice prominent; vaccine history relevant IgM serology / PCR

If you may have been exposed

  1. Isolate immediately in a separate room with a closed door if possible.
  2. Call ahead before going to any healthcare facility. Walking into an unprepared clinic risks transmission to staff and other patients.
  3. Mention the exposure: specify which country, which province, which dates, and any contact with sick or deceased persons or with bats and primates.
  4. Do not self-medicate with antibiotics or antimalarials before laboratory testing; this can mask diagnosis.
  5. In Germany dial 112; in the UK dial 111; in the US dial your state health department. Other countries: contact the WHO emergency number for your region.

This page is reference material, not a substitute for clinical evaluation by a qualified healthcare professional.